The Maserati 450S (Tipo 54) was a racing car produced for participation in FIA World Endurance Championship races in the years 1956-1958. Only 9 examples were produced in total. The car was rear-wheel drive, with the engine mounted in the front, and was produced as a 2-door roadster and coupe. Development of the 450S began in 1954.  It began with the development of the engine, which was a 4.5-litre V8 with 400 hp (300 kW), mated to a 5-speed manual gearbox.

The prototype made its racing debut at the 1956 Swedish Grand Prix, but despite its impressive performance, it exhibited various shortcomings. The chassis was unable to handle the power of the engine and qualified third in the practice session. After modifications and several unsuccessful attempts, the car won the 12 Hours of Sebring.